Superantigens is the first comprehensive examination of these fascinating proteins ever published. Organized into five sections and sixteen chapters, this volume provides an essential overview of many aspects of superantigen biology. A team of internationally respected researchers covers the basic molecular mechanisms of superantigen action, their structure and function, and their role in human diseases. Additionally, Superantigens explains the clinical consequences of superantigen intoxication and the latest therapeutic interventions to combat superantigen toxicity.
This volume emphasizes how newly discovered structural variations among superantigens affect their interactions with human immune cells. Most importantly, these structural and functional differences help explain the exacerbation of certain diseases and why certain superantigens are more effective in some tissues and not in others. Furthermore, the book emphasizes how this information can inform new research on the design and development of new intervention strategies to ameliorate superantigen responses in severe acute infections or chronic illnesses. Special attention is paid to the latest findings on staphylococcal, streptococcal, and mycoplasma toxins and their relationship to specific diseases. Finally, the potential for the use of superantigens in bioterrorism is discussed.
